Millions of people worldwide suffer from psoriatic arthritis (PsA), a chronic inflammatory disease that frequently develops in those who also have psoriasis, a skin illness marked by red, scaly patches. PsA can cause severe joint damage, including pain, stiffness, and oedema, in addition to its effects on the skin. There is more, though, as new …
Millions of people worldwide suffer from psoriatic arthritis (PsA), a chronic inflammatory disease that frequently develops in those who also have psoriasis, a skin illness marked by red, scaly patches. PsA can cause severe joint damage, including pain, stiffness, and oedema, in addition to its effects on the skin. There is more, though, as new research points to a complex relationship between PsA and blood uric acid levels.
Gout is a kind of arthritis largely caused by the body’s natural waste product, serum uric acid, which is produced when purines are broken down. On the other hand, recent data suggests that serum uric acid levels could also impact the development and course of PsA. There may be a connection between PsA and elevated blood uric acid levels since some PsA patients have shown these results.
For complete patient care, it is essential to comprehend this link. Kayakalp Global, the leading medical facility known for its holistic approach, understands the significance of examining the relationship between PsA and serum uric acid.
At the pinnacle of providing individualized care to patients battling PsA and associated illnesses is Kayakalp Global, which combines cutting-edge diagnostic procedures with cutting-edge therapy modalities. Kayakalp Global keeps expanding its knowledge of PsA and serum uric acid by continuously working with and closely monitoring patients. This helps to enhance treatment approaches and patient results globally.
Understanding Psoriatic Arthritis
A chronic autoimmune illness, psoriatic arthritis (PsA) mostly affects the joints, however, it can also affect the skin and other organs. Here’s a summary of the main points:
- Symptoms: PsA symptoms can vary greatly, but they frequently include swelling, stiffness, and joint discomfort. They are also accompanied by skin symptoms such as red, scaly patches that are indicative of psoriasis.
- Joint Involvement: PsA may impact every joint in the body, including the elbows, knees, fingers, toes, and spine. In rare circumstances, joint inflammation can result in permanent harm and abnormalities.
- Subtypes: PsA has several subtypes, such as spondylitis (inflammation of the spine), symmetric arthritis (affecting the same joints on both sides of the body), and asymmetric arthritis (affecting different joints on each side).
- Triggers: Although the precise origin of PsA is unclear, immunological system malfunction and genetic factors are thought to be involved. Furthermore exacerbating symptoms are triggers including diseases, trauma, and stress.
- Diagnosis: To confirm the existence of inflammation and rule out other illnesses, a combination of laboratory testing, imaging tests (such as MRIs and X-rays), physical examinations, and medical histories is usually used to diagnose PsA.
Comprehending PsA is essential for prompt diagnosis and treatment to avert long-term issues and enhance the standard of life for those who endure this difficult illness.
Understanding Serum Uric Acid
The body produces serum uric acid (SUA) as a byproduct of breaking down purines, chemicals present in some diets and tissues. Here’s a thorough explanation:
- Metabolism: The liver’s xanthine oxidase enzyme converts purines into uric acid. After that, uric acid dissolves in the circulation and is mostly eliminated in urine by the kidneys.
- Function: Although uric acid is frequently linked to gout, debilitating arthritis, it also acts as an antioxidant in the body, guarding against oxidative stress and neutralizing free radicals.
- Association with Diseases: Gouty arthritis is caused by urate crystals that grow in the joints due to high uric acid levels. Higher SUA levels have also been connected to cardiovascular disease, hypertension, and kidney stones, among other medical disorders.
- Testing: A straightforward blood test may be used to determine the serum uric acid levels. It is frequently advised for those who are gouty or who have risk factors including obesity, a diet strong in purine-rich foods, or a family history of gout.
Knowing blood uric acid levels is crucial for gout diagnosis and treatment, as well as for determining the likelihood of any related health issues. Maintaining SUA levels within a safe range and preventing associated disorders can be achieved with regular monitoring and suitable lifestyle adjustments.
Is There A Relationship Between Serum Uric Acid And Psoriatic Arthritis?
Serum uric acid (SUA) levels and psoriatic arthritis (PsA) have a complicated relationship that should be taken into account while treating the condition. SUA levels are commonly elevated in PsA patients, a chronic inflammatory disease of the skin and joints that signifies hyperuricemia.
Because PsA inflammation activates certain bodily pathways and substances, it increases SUA synthesis. This much uric acid can exacerbate swollen joints and perhaps lead to additional problems such as gout.
Furthermore, the joint issues associated with PsA may raise SUA levels even further. Urate crystals are released by inflammatory joints, exacerbating the condition and causing more damage.
SUA levels may potentially be impacted by PsA treatment. Certain PsA medications, such as corticosteroids, can cause SUA levels to rise by increasing the formation of uric acid and decreasing the amount that the kidneys can excrete. However, some medications, such as some disease-modifying ones, may reduce SUA levels by reducing inflammation.
Effective management of the condition requires an understanding of the relationship between PsA and SUA levels. Regularly measuring SUA levels can assist in identifying individuals at risk for gout, determine the degree of disease activity, and guide treatment decisions. By addressing both hyperuricemia and joint inflammation, medical professionals can better plan therapies and improve the quality of life for PsA patients.
Normal Range of Serum Uric Acid Test
Serum uric acid (SUA) levels tend to vary within the normal range based on age, sex, and underlying medical problems. SUA typically ranges from 3.4 to 7.0 mg/dL (milligrams per deciliter) in men and from 2.4 to 6.0 mg/dL in women. However, depending on the people being tested and the reference range of the laboratory, these numbers could change slightly.
While high levels of SUA may be a sign of renal illness, gout, or certain metabolic abnormalities, low levels may signal ailments such as Wilson’s disease or Fanconi syndrome.
| Parameter | Normal Range (mg/dL) | Low Range (mg/dL) | High Range (mg/dL) |
| Men | 3.4 – 7.0 | Below 3.4 | Above 7.0 |
| Women | 2.4 – 6.0 | Below 2.4 | Above 6.0 |
SUA levels can be influenced by many things, such as lifestyle choices, drugs, food, and underlying medical illnesses including metabolic or renal diseases. Medication like diuretics and immune suppressors may alter uric acid metabolism, while some purine-rich meals like red meat, shellfish, and alcohol can raise uric acid production. Accurately interpreting test findings and managing problems associated with elevated uric acid levels need an understanding of the typical range of SUA and the variables that influence it.
The Procedure of The Serum Uric Acid Test
Serum uric acid testing is a straightforward process that usually requires a blood sample. A tiny blood sample will be drawn for the test by a medical practitioner, generally from an arm vein.
It is usually advised to fast for a few hours before the test to ensure reliable findings, avoiding food and liquids to save water. After that, the blood sample is transported to a lab for examination. The amount of uric acid in the blood is measured by lab professionals.
Usually, the findings are ready in a few days. The serum uric acid test is a simple and widely used technique to determine the body’s uric acid levels, offering important information for the diagnosis and treatment of diseases including psoriatic arthritis and gout.
Cost Of Serum Uric Acid Test
Serum uric acid test costs might differ based on many factors, including the medical facility’s location, any extra tests needed, and whether the test is performed in a private laboratory or a hospital. In India, the price typically falls between ₹300 and ₹800.
However, costs might vary depending on the healthcare provider and the particular area. It’s wise to find out the precise price and any possible deals or packages that nearby healthcare institutions can provide.
Psoriatic Arthritis Test & Frequency
| Psoriatic Arthritis Test | Frequency |
| Psoriatic Arthritis Test: X-Ray | Annually |
| Psoriatic Arthritis Test: MRI | Every 2 Years |
| Psoriatic Arthritis Test: Erythrocyte Sedimentation Rate | Quarterly |
| Psoriatic Arthritis Test: C-Reactive Protein | Quarterly |
| Psoriatic Arthritis Test: Rheumatoid Factor | Annually |
| Psoriatic Arthritis Test: Anti-Cyclic Citrullinated Peptide Test | Annually |
| Psoriatic Arthritis Test: HLA-B27 | Once (if indicated) |
| Psoriatic Arthritis Test: Complete Blood Count (CBC) | Every 6 Months |
| Psoriatic Arthritis Test: Tuberculosis Test | Annually (if on immunosuppressants) |
| Psoriatic Arthritis Test: Chest X-Ray | Annually |
| Psoriatic Arthritis Test: Serum Uric Acid | Annually |
| Psoriatic Arthritis Test: Bone Mineral Density | Every 2 Years |
| Psoriatic Arthritis Test: Anemia | Every 6 Months |
| Psoriatic Arthritis Test: Thyroid Function Tests | Annually |
| Psoriatic Arthritis Test: Skin Biopsy | As needed (if skin symptoms change) |
Caution Note: The frequency of these tests can vary based on individual patient conditions and physician recommendations. Regular follow-ups with a healthcare provider are essential to determine the appropriate testing schedule.
Kayakalp Global At The Pinnacle Of Healthcare & Wellbeing
When it comes to negotiating the complexity of serum uric acid (SUA) levels and psoriatic arthritis (PsA), Kayakalp Global stands out as a leader in comprehensive treatment and creative solutions. Understanding the complex relationship between SUA and PsA, Kayakalp Global takes a proactive stance to guarantee precise diagnosis and efficient treatment.
Through the integration of cutting-edge serum uric acid testing techniques, Kayakalp Global enables medical professionals to get a deeper understanding of the dynamics of illness, facilitating prompt interventions and customised treatment regimens. Kayakalp Global improves patient outcomes and quality of life by identifying patients who are at risk of developing problems such as gout and tracking the evolution of the disease by regular monitoring of SUA levels.
Furthermore, by targeting the underlying inflammatory processes prevalent in PsA, Kayakalp Global’s integrated therapy approach goes beyond symptom management. To optimize patient health and well-being holistically, Kayakalp Global combines traditional medicines with dietary guidance, lifestyle adjustments, and holistic interventions.
Beyond the confines of traditional medicine, Kayakalp Global is dedicated to providing exceptional PsA management. The company adopts a holistic paradigm that prioritizes patient care and empowerment. People with Parkinson’s disease (PsA) can find comfort in a holistic healthcare environment that supports recovery, resiliency, and vitality with Kayakalp Global.
