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Anti-Cyclic Citrullinated Peptide Test Psoriatic Arthritis: Normal Range, Procedure, Cost

Anti-Cyclic Citrullinated Peptide Test

Prominent for its all-inclusive medical solutions, Kayakalp Global stresses the significance of using anti-CCP testing in the PsA diagnosis procedure. By using this test, medical professionals may guarantee a more precise diagnosis, resulting in more individualised and successful treatment regimens for patients.

The integrated approach demonstrates Kayakalp Global’s dedication to offering comprehensive, patient-centered care to those with Parkinson’s disease.

Psoriatic arthritis (PsA) is a skin and joint inflammatory disease that usually develops in people who have psoriasis. PsA, which is characterised by swelling, stiffness, and joint discomfort, can seriously lower a person’s quality of life. An accurate and timely diagnosis is essential for good management and care.

The Anti-Cyclic Citrullinated Peptide (anti-CCP) antibody is a crucial diagnostic for the diagnosis and comprehension of PsA. The immune system produces anti-CCP antibodies, which are proteins that specifically target citrullinated proteins, which are frequently seen in inflammatory diseases like PsA. Anti-CCP antibodies in the blood can aid in PsA diagnosis and help differentiate it from other types of arthritis, such as rheumatoid arthritis.

What Is Anti-Cyclic Citrullinated Peptide

Immune system proteins known as anti-cyclic Citrullinated Peptide (anti-CCP) antibodies specifically target citrullinated proteins, which are produced when certain amino acids in proteins are changed. The immune system may target these altered proteins, causing inflammation and joint injury. Anti-CCP antibodies can be important in the diagnosis of psoriatic arthritis (PsA) and are closely linked to autoimmune diseases such as rheumatoid arthritis.

Highly specific indicators for inflammatory arthritis are anti-CCP antibodies. By helping to distinguish PsA from other forms of arthritis, their identification can provide vital information for a proper diagnosis and course of therapy. Increased anti-CCP antibody levels frequently signify a more aggressive course of the disease, which might influence prognosis and therapy choices.

A straightforward blood test is used to check for anti-CCP. The findings can help medical professionals create a thorough treatment strategy catered to each patient’s specific requirements. Comprehending and evaluating anti-CCP is an essential aspect of PsA management, guaranteeing that patients obtain optimal therapy.

Psoriatic Arthritis

Skin and joints are both impacted by the long-term inflammatory disease known as psoriatic arthritis (PsA). It frequently affects those who have psoriasis, a skin condition marked by red, scaly areas. Though PsA can occur at any age, it usually manifests itself in people between the ages of 30 and 50. Men and women are equally affected by the condition, which can manifest differently and vary greatly in severity.

Being an autoimmune illness, PsA results from the body’s immune system attacking its tissues by mistake, producing inflammation and tissue damage. Joint discomfort, swelling, stiffness, and decreased range of motion are the main signs of this inflammation.

Effective PsA management requires early diagnosis and therapy. PsA can cause joint injury and disability if left untreated. Physical therapy is sometimes used together with medicine to preserve joint function and minimise inflammation, as well as lifestyle modifications to enhance general health. Personalised treatment regimens and routine monitoring are necessary to enhance the standards of life for people with PsA.

Connection Between Anti-Cyclic Citrullinated Peptide and Psoriatic Arthritis

Rheumatologists are becoming increasingly interested in the connection between anti-cyclic citrullinated peptide (anti-CCP) and psoriatic arthritis (PsA). Another kind of inflammatory arthritis called rheumatoid arthritis (RA) is mostly linked to anti-CCP antibodies. Recent research has revealed that these antibodies may also be present in certain PsA patients, which sheds light on the disease’s complexity and facilitates diagnosis and treatment.

Anti-CCP antibodies in the blood may indicate that rheumatoid arthritis (RA)-like immunological responses are occurring in PsA patients. These antibodies target alterations made to particular proteins within the body. This alteration is believed to be connected to the way that autoimmune disorders such as PsA and RA cause the immune system to begin attacking the body.

PsA patients with elevated anti-CCP antibody levels may have a more serious illness course and have a greater likelihood of joint injury. A blood test can identify these antibodies, giving medical professionals important information. Even though not every PsA patient will have positive anti-CCP antibody tests, those who do might need more intensive care to adequately manage their disease.

Comprehending the existence of anti-CCP antibodies in individuals with PsA is crucial for precise diagnosis and customised therapeutic approaches. It aids in distinguishing PsA from other types of arthritis, guaranteeing that patients get the best possible therapy. When paired with additional diagnostic instruments, routine anti-CCP level monitoring can enhance PsA patient outcomes and disease management.


Anti-Cyclic Citrullinated Peptide Test Normal Range

The anti-cyclic citrullinated peptide (anti-CCP) test typically has a normal range of fewer than 20 units per milliliter (U/mL). Depending on the laboratory and the particular test procedure utilised, this range may differ significantly. Above this range, higher anti-CCP antibody levels may be associated with a higher risk of autoimmune diseases such as psoriatic arthritis (PsA) or rheumatoid arthritis (RA).

Anti-CCP Test LevelInterpretation
LowLess than 20 U/mL
NormalLess than 20 U/mL
HighAbove 20 U/mL


Because of its exceptional accuracy in identifying the antibodies, the CCP2 test is regarded as the benchmark for anti-CCP testing. It aids in distinguishing PsA from other types of arthritis, including RA, and offers useful data for modifying treatment plans. Healthcare professionals can more accurately forecast the course of the disease and put in place suitable management strategies by recognising patients with anti-CCP antibodies, guaranteeing that people with PsA receive the best care possible.

Anti-Cyclic Citrullinated Peptide Test Procedure

The anti-cyclic citrullinated peptide (anti-CCP) test protocol is simple to follow and requires many procedures to guarantee precise findings.

  • Pre-Test Preparation: Patients usually speak with their doctor before the test to go over their symptoms, medical background, and current medicines. Unless instructed otherwise by the healthcare professional, fasting is typically not necessary for the anti-CCP test, in contrast to some blood tests.
  • Blood Sample Collection: Usually from an arm vein, a certified phlebotomist or other medical practitioner will take a blood sample during the session. After using an antiseptic swab to clean the region, a tourniquet is used to highlight the vein. Blood is drawn into a vial or syringe after a sterile needle is introduced into the vein. The procedure normally takes only a few minutes and there’s little discomfort.
  • Lab Analysis: After being labeled, the blood sample is delivered to a lab for examination. Immunoassay procedures are used in the lab to test the sample for the existence of anti-CCP antibodies. Because of the CCP2 test’s excellent sensitivity and specificity, it is often employed. The healthcare provider receives a return copy of the results. Usually, this procedure takes a couple of days.
  • Post-Test Consultation: Following the release of test results, patients schedule a follow-up consultation with their Kayakalp Global specialist to go over the results. The experts evaluate the findings in light of the patient’s symptoms, past medical conditions, and results from other diagnostic testing. An autoimmune disease such as PsA or RA may be present if anti-CCP antibody testing is positive.
  • Next Steps: Depending on the findings, Kayakalp Global experts could suggest more examinations or begin a customised treatment regimen for the patient.

This all-encompassing method guarantees precise diagnosis and efficient treatment of illnesses such as PsA, underscoring the significance of the anti-CCP test in clinical practice.


Citrullinated Peptide Anti-Cyclic Test Cost

The location of the laboratory, the kind of medical institution, and whether or not other tests are conducted concurrently are some of the variables that might affect the price of an anti-cyclic citrullinated peptide (anti-CCP) test. An anti-CCP test often costs between ₹1,500 and ₹3,500 in India. The cost of private hospitals and specialised diagnostic centres may be higher than that of non-profit or government-run institutions.

Patients should inquire about costs, possible packages, and discounts from several laboratories. To save costs, several healthcare facilities provide testing packages that contain the anti-CCP test in addition to other pertinent diagnostic procedures. Before starting the test, always make sure you have the entire fee confirmed with the healthcare practitioner.

Psoriatic Arthritis Test & Frequency

Psoriatic Arthritis TestFrequency
Psoriatic Arthritis Test: X-RayAnnually
Psoriatic Arthritis Test: MRIEvery 2 Years
Psoriatic Arthritis Test: Erythrocyte Sedimentation RateQuarterly
Psoriatic Arthritis Test: C-Reactive ProteinQuarterly
Psoriatic Arthritis Test: Rheumatoid FactorAnnually
Psoriatic Arthritis Test: Anti-Cyclic Citrullinated Peptide TestAnnually
Psoriatic Arthritis Test: HLA-B27Once (if indicated)
Psoriatic Arthritis Test: Complete Blood Count (CBC)Every 6 Months
Psoriatic Arthritis Test: Tuberculosis TestAnnually (if on immunosuppressants)
Psoriatic Arthritis Test: Chest X-RayAnnually
Psoriatic Arthritis Test: Serum Uric AcidAnnually
Psoriatic Arthritis Test: Bone Mineral DensityEvery 2 Years
Psoriatic Arthritis Test: AnemiaEvery 6 Months
Psoriatic Arthritis Test: Thyroid Function TestsAnnually
Psoriatic Arthritis Test: Skin BiopsyAs needed (if skin symptoms change)

Caution Note: The frequency of these tests can vary based on individual patient conditions and physician recommendations. Regular follow-ups with a healthcare provider are essential to determine the appropriate testing schedule.

Psoriatic Arthritis Management & Treatment With Kayakalp Global

At Kayakalp Global, we recognise that anti-cyclic citrullinated peptide (anti-CCP) testing is an essential part of the treatment of psoriatic arthritis. Our integrated approach makes us leaders in the treatment of psoriasis and guarantees our patients’ total well-being. Anti-CCP testing aids in the prompt and focused intervention of PsA by facilitating an accurate and early diagnosis.

Our specialists can effectively evaluate the activity and course of the illness by routinely monitoring anti-CCP levels, and they may customise treatment strategies to meet the specific needs of each patient. This all-encompassing approach helps avoid long-term joint injury in addition to discomfort relief.

Patients at Kayakalp Global receive the best care possible, addressing the physical and emotional health elements of psoriatic arthritis. This is made possible by our dedication to fusing ancient Ayurvedic knowledge with cutting-edge medical techniques.

Anti-CCP testing is a way that we demonstrate our commitment to providing comprehensive healthcare solutions. Patients may rely on a comprehensive, patient-centered approach to psoriatic arthritis management with Kayakalp Global, which enhances quality of life.

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